Thiosulfonate Switch Technique - a three step protocol for detection of S-nitrosylated proteins (GPA-2014-TST)


Status: Available for Non-Exclusive Licensing

Contact: Nick Zelver, 406-994-7706

Thiosulfonate switch technique: a new three step protocol for SNO detection in aqueous medium that traps protein S-nitrosothiols as mixed disulfides bearing a fluorescent probe at pH 4.0. 

Thiosulfonate Switch Technique - a three step protocol for detection of S-nitrosylated proteins

Novel Dyes for Proteomic Research, Drug Development and Diagnostics (DEA-2013-DYES)


Status: Available for Licensing

Contact: Nick Zelver, 406-994-7706

Researchers at Montana State University have developed optical labeling molecules - dyes - that possess increased detection sensitivity. These water-soluble Zwitterionic dyes also enable recovery of intact proteins and allow for versatile, high speed, multiplex analysis for proteomics.

Patents:
US 7,833,799
US 8,197,758
US 8,197,759

Publications:
Proteomic analysis of Sulfolobus solfataricus during Sulfolobus Turreted Icosahedral Virus infection
Proteomic and Systems Biologys Analysis of Monocytes Exposed to Securinine, a GABAA Receptor Antagonist and Immune Adjuvant

Trimodal Handheld Probe Based on Raman Spectroscopy and Confocal Imaging for Cancer Detection (DD-2008-PROBE)

Jointly developed with Vanderbilt University (link to VU website above).


Status: Available for Licensing

Contact: Nick Zelver, 406-994-7706

A single handheld device for combined confocal imaging and confocal Raman spectroscopy as well as gross spatial imaging as a clinical diagnostic tool for cancer detection in humans, with a specific emphasis on the skin. 

Biomedical Optics paper: Handheld Scanning Confocal Raman microspectroscopy system

MSU News article: MSU grad's work helps diagnose skin cancer without a biopsy

Patent:
US 8,300,220

Novel Agents to Enhance Tolerance to an Immunogen (PDW-2006-TOLE)


Status: Exclusively Licensed

Contact: Nick Zelver, 406-994-7706

A new approach to developing highly potent, antigen-specific agents, called "tolerizing agents", uses a mucosal targeting ligand fused to a specific antigen to induce host unresponsiveness solely to that antigen while avoiding global immune suppression.

Novel Agents to Enhance Tolerance to an Immunogen

Patent:
US 7,910,113

Quaternary Ammonium Complex Provides Superior Broad Spectrum Antimicrobial Activity (CMJ-2005-CARB)


Status: Available for Licensing

Contact: Nick Zelver, 406-994-7706

Binding biocide to soluble dendrimers targets and disrupts the cell wall providing a new approach to controlling household, industrial, and medical microorganisms.

Quaternary Ammonium Complex Provides Superior Broad Spectrum Antimicrobial Activity

Patent:
US 8,329,155

Mouse Monoclonal Antibodies

 

Status: Available for Non-Exclusive Licensing

Contact: Nick Zelver, 406-994-7706

Anti-gp91phox, Anti-p22phox and Anti- CAP-18

Mouse Monoclonal Antibodies